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KMID : 0857020100250010001
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Kosin Medical Journal
2010 Volume.25 No. 1 p.1 ~ p.9
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Effective CancerTherapy: Effect of TRAIL/induced Apoptosis
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Kim Young-Ho
Heo Jeong-Hoon
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Abstract
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TRAIL (TNF-a Related Apoptosis-Inducing Ligand) is a promising anticancer agent. In fact, it induces apoptosis in cancer cells but not in most normal cells. Nevertheless, certain cancer cells are resistant to TRAIL-induced apoptosis and this could limit TRAIL’s efficiency in cancer therapy. To overcome TRAIL resistance, a combination of TRAIL with chemotherapy could be used in cancer treatment. This review describes that TRAIL-resistant tumors can be re-sensitized to TRAIL by a combination of TRAIL with chemotherapeutics. In addition, it has been shown that chemotherapeutic drugs have also been shown to enhance the induction of apoptosis by TRAIL or agonistic antibodies or overcome cell resistance to TRAIL or agonistic antibodies. Therefore, death receptors, particularly TRAIL death receptors, have emerged as an important cancer therapeutic target. This review suggests novel strategies for TRAIL resistance cancer treatment as the effective cancer therapy of TRAIL induced apoptosis in cancer cells.
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KEYWORD
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TNFa-Related Apoptosis-inducing Ligand (TRAIL), Apoptosis, chemopreventive agents
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